Boosts Cognitive Function

Pregnenolone acts as a nootropic agent, enhancing various aspects of cognitive function such as memory, learning, and thinking skills.

Studies indicate that pregnenolone improves cognitive function through several key mechanisms:

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- It serves as a signaling molecule in the brain, stimulating neuron activity.
- Pregnenolone promotes the growth of neurons.
- It enhances myelination, improving the transmission of electrical signals.
- The hormone supports the survival of new neurons.
- Pregnenolone aids in the recovery of neurons.
- It protects neurons from cell toxicity and toxin-induced cell death.
- In older adults, lower levels of pregnenolone are linked to a higher risk of dementia.
- Pregnenolone regulates neuronal function by activating and deactivating various signaling pathways.
- It helps stabilize neurons and stimulate their development.
- Animal studies show that pregnenolone enhances learning and memory performance.
- It improves performance in maze tests in mice and rats.
- Pregnenolone can block amnesia induced by certain chemicals.

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Stimulates Deep Sleep

Pregnenolone deficiency can significantly disrupt sleep patterns and quality. As a pro-hormone responsible for producing vital sex hormones, healthy levels of pregnenolone can promote deep sleep. Research highlights the connection between pregnenolone and normal sleep patterns:

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- Supplementation increases the amount of time spent in deep sleep for those with sleep difficulties.
- It improves overall sleep quality by affecting wakefulness.
- Pregnenolone plays a role in regulating the sleep-wake cycle.
- In men, pregnenolone administration induces changes in sleep-related brain activity.

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Relieves Schizophrenia Symptoms

Schizophrenia is a long-term mental health condition characterized by various psychological symptoms. Current treatments include antipsychotic medications and cognitive behavioral therapy.

Emerging evidence suggests that pregnenolone may be a therapeutic option for this condition:

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- In individuals with schizophrenia and schizoaffective disorder, pregnenolone treatment reduces the severity of negative symptoms.
- It improves attention and verbal working memory in schizophrenia patients.
- Low-dose pregnenolone, when combined with antipsychotics, can reduce side effects of the medications.
- In animal models, pregnenolone lessens schizophrenia-like symptoms and prevents cognitive deficits.

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Improves Mood and Wards off Depression

Lower levels of pregnenolone are strongly associated with depressive mood. Given the challenges of treating depression, research into pregnenolone’s effects on mood could be significant:

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- In women with bipolar disorder, higher levels of pregnenolone correlate with stable mood states.
- Pregnenolone boosts mood by activating neurocircuits that regulate emotion.
- Blocking its production can impair social and emotional functioning.
- In patients with bipolar disorder and major depressive disorder, pregnenolone supplementation reduces depressive symptoms.
- It promotes neuronal growth by stabilizing microtubule function, which is disrupted in depressive disorders.
- Individuals with generalized anxiety disorder tend to have lower pregnenolone levels.
- Preclinical findings suggest pregnenolone is important in anxiety and depression regulation.
- Patients in depressive episodes have lower pregnenolone levels compared to healthy controls.
- Supplementation has been shown to reduce self-reported anxiety.
- In adults with autism spectrum disorder, pregnenolone can decrease irritability.
- It enhances mood by activating the brain chemical GABA.

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Strengthens the Immune System

As we age, the immune system often weakens, increasing susceptibility to infections.

Pregnenolone has immune-modulating properties that can enhance immune response:

- Synthetic derivatives of pregnenolone exhibit antiviral properties against the herpes simplex virus.
- It helps restore immune balance by suppressing excessive immune responses.
- Pregnenolone is involved in the physiological regulation of the body's immune functions.
- It strengthens the immune system by enhancing inflammatory responses.